Open AccessMethyl jasmonate: a phytohormone with potential for the treatment of inflammatory bowel diseases
Author(s) -
Besson Jean Carlos Fernando,
Carvalho Picoli Caroline,
Matioli Graciette,
Natali Maria Raquel Marçal
Publication year - 2018
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/jphp.12839
Subject(s) - methyl jasmonate , neuroprotection , jasmonate , microbiology and biotechnology , apoptosis , mechanism of action , signal transduction , biology , pharmacology , chemistry , biochemistry , in vitro , arabidopsis , mutant , gene
Objectives The phytohormone methyl jasmonate (Me JA ) has been identified as a vital cell regulator in plants. This substance is analogous to eicosanoids and similar to that of anti‐inflammatory prostaglandins. In animals and in animal cells, it displayed an efficient neuroprotective, anti‐inflammatory and antioxidant action; while in tumoral strains, it demonstrates a potentially highly attractive mechanism of apoptosis induction through various cellular and molecular mechanisms. The aim of the present review was to explore two new hypotheses that explain the action of Me JA , a lipid phytohormone and its potentially anti‐apoptotic mechanism for use as a therapeutic target for future treatment of Inflammatory bowel diseases ( IBD s). Key findings Methyl jasmonate is a new candidate for the treatment of IBD s, modulating the expression of the major classes of caspase‐type protease families that selectively act on the extrinsic and intrinsic pathways of the apoptotic process. Its action is based on the reduction of the expression in tumour necrosis factor tissue levels and the modulating action of reactive oxygen species production, acting only on the destruction of cells that express the diseased phenotype, and preserving cells that are not transformed. Conclusions Methyl jasmonate may represent an alternative for the transduction processes of important signals in the cellular renewal of the intestinal mucosa.