Open AccessRecommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties: a review
Author(s) -
Martir Joana,
Flanagan Talia,
Mann James,
Fotaki Nikoletta
Publication year - 2017
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/jphp.12635
Subject(s) - biopharmaceutical , medicine , context (archaeology) , food and drug administration , population , dosing , health professionals , administration (probate law) , intensive care medicine , pharmacology , health care , environmental health , microbiology and biotechnology , paleontology , economics , biology , economic growth , political science , law
Objectives This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties. Key findings Acceptability of oral medicines in young patients is more challenging than in adult patients. Mixing oral dosage forms with foods and drinks is sometimes suggested to administer a specific dose and enhance compliance in the paediatric population. In this review, the strategies for the co‐administration of paediatric medicines with food and drinks are discussed. Current administration practices as reported by healthcare professionals and parents/carers are compared with the relevant guidelines. Differences in the type of vehicles recommended to be used and actually used in current practice were identified. Correlations of the type of food recommended, the type of formulation and the drug's biopharmaceutical classification system ( BCS ) class were performed and revealed that recommendations should be made on a case‐by‐case basis. Summary The propensity for physiochemical or bioavailability changes that may occur from the co‐administration of medicines with food and drinks in the paediatric population should be considered, and harmonisation of the recommended administration strategies is needed.