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Meconium aspiration syndrome: incidence, associated risk factors and outcome‐evidence from a multicentric study in low‐resource settings in Nepal
Author(s) -
Paudel Prajwal,
Sunny Avinash K,
Poudel Pragya G,
Gurung Rejina,
Gurung Abhishek,
Bastola Ramchandra,
Chaudhary Ram N,
Budhathoki Shyam S,
Ashish K C
Publication year - 2020
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.14703
Subject(s) - medicine , odds ratio , incidence (geometry) , meconium aspiration syndrome , confidence interval , obstetrics , pregnancy , pediatrics , observational study , meconium , fetus , physics , biology , optics , genetics
Aim The aim of this study was to identify the incidence, risk factors and outcome associated with meconium aspiration syndrome (MAS). Methods An observational study was conducted in 12 public hospitals in Nepal from 1 July 2017 to 29 August 2018. All babies born within the study period were included in the study. Babies who were diagnosed as MAS were designated as outcome. Data were analysed with bivariate analysis followed by multiple regression analysis. Results The overall incidence of MAS was 2.0 per 1000 livebirths. Babies born at post‐term gestation (adjusted odds ratio (AOR) = 2.41; 95% confidence interval (CI): 1.05–5.55), nulliparity (AOR = 2.26; 95% CI: 1.20–4.28), instrumental delivery (AOR = 4.79; 95% CI: 2.52–9.10) and caesarean delivery (AOR = 3.67; 95% CI: 2.29–5.89) were significantly associated with MAS. Babies with MAS had a 10‐fold risk for pre‐discharge mortality (odds ratio = 9.87; 95% CI: 5.81–16.76). Conclusions The findings in this study are consistent with that reported in other studies. MAS has a high risk of neonatal mortality. Thus, monitoring during pregnancy and labour is necessary for early identification of high‐risk conditions associated with MAS. Strengthening of newborn care services is essential to curtail mortality.