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Correlation of anti‐Mullerian hormone with humanchorionic gonadotropin test in the evaluation of testicular function of children with 46 XY male hypogonadism: Use of anti‐Mullerian hormone as abiomarker
Author(s) -
Karaoglan Murat
Publication year - 2020
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.14643
Subject(s) - medicine , anti müllerian hormone , concordance , human chorionic gonadotropin , testosterone (patch) , hormone , hypogonadotropic hypogonadism , endocrinology , biomarker , gonadotropin , gynecology , biology , biochemistry
Aim It is challenging to evaluate reproductive potential during childhood. These challenges necessitate the use of invasive dynamic tests. Although the anti‐Mullerian hormone (AMH) is a reliable biomarker in evaluating testicular function, especially in the pre‐pubertal period, there are uncertainties concerning its use in a clinical setting. This study is focused on comparing the AMH and human chorionic gonadotropin (hCG) test in boys with hypogonadism. Methods A total of 160 boys aged between 0 and 18 years who presented with complaints associated with hypogonadism were prospectively enrolled in the study. All children were assigned to the following five groups: gonadal disorders ( n = 34), androgen synthesis and end organ effect disorder ( n = 48), isolated genital malformation disorders ( n = 57), hypogonadotropic hypogonadism ( n = 15) and constitutional delayed puberty ( n = 6). All children underwent a short 3‐day hCG test (1500 U/m 2 /day). The concordance and correlation were evaluated between the hCG test and AMH. Results All groups exhibited a strong correlation ( r 160 = 0.689) and strong concordance (Kappa coefficient 160 = 0.7) between the AMH and hCG test. Values of AMH higher than 32.7 pmol/L and hCG responses higher than 86 pmol/L were significant as indicative markers of functional testicular tissue presence. Conclusions This study has shown that there is a strong correlation between the AMH and short‐term hCG test and that values of AMH higher than 32.7 pmol/L and stimulated testosterone higher than 86 pmol/L can be used as indicators of functionally sufficient testicular tissue. These results indicate that AMH value can be used as a reliable and useful biomarker in the evaluation of the testicular function in 46 XY hypogonadism.