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Methadone versus morphine treatment outcomes in neonatal abstinence syndrome: A meta‐analysis
Author(s) -
Xiao Feifan,
Yan Kai,
Zhou Wenhao
Publication year - 2019
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.14609
Subject(s) - medicine , methadone , meta analysis , confidence interval , cochrane library , abstinence , strictly standardized mean difference , morphine , relative risk , randomized controlled trial , opioid , medline , anesthesia , psychiatry , receptor , political science , law
Aim To determine whether morphine has better outcomes for neonatal abstinence syndrome treatment than methadone. Methods Studies published before 1 January 2019 were identified using the PubMed, Web of Science, Scopus, Cochrane Library and ClinicalTrials.gov databases. The Cochrane Collaboration Risk of Bias Tool was used to assess the risk of bias for randomised clinical trials. In addition, the risk of bias for non‐randomised studies was evaluated by a non‐randomised studies of interventions tool. Results We identified 1020 published studies, and 5 were included in the final analysis. Results showed no significant difference in opioid treatment days (standardised mean difference (SMD) = 0.32, 95% confidence interval (CI) = −0.16, 0.80), length of hospital stay (SMD = −0.33, 95% CI = −1.21, 0.56) and duration of treatment (SMD = −0.83 95% CI = −2.09, 0.43) between morphine or methadone treatment. Conclusions Our meta‐analysis of current evidence demonstrated that neonatal abstinence syndrome treatment with morphine was not associated with better outcomes in infants compared with methadone treatment.