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The diagnostic value of ischaemia‐modified albumin in acute abdominal pain
Author(s) -
Sarac Fatma,
Yeniocak Selman,
Buyukbese Sarsu Sevgi,
Sahin Kamil,
Yucetas Esma,
Koldas Macit,
Katipoglu Burak
Publication year - 2019
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.14394
Subject(s) - medicine , white blood cell , abdominal pain , differential diagnosis , acute abdominal pain , emergency department , appendicitis , ischemia modified albumin , surgery , ischemia , myocardial ischemia , pathology , psychiatry
Aim The differential diagnosis of paediatric patients admitted to the emergency department presenting with acute abdominal pain may be difficult. This study aims to investigate the diagnostic value of ischaemia‐modified albumin (IMA) in the differential diagnosis of acute abdominal pain in children and in distinguishing surgical from non‐surgical cases. Methods The study was conducted with a total of 152 subjects who provided informed consent, including 112 patients admitted to the paediatric emergency department and paediatric surgical clinic and 40 healthy control subjects. Blood samples were collected after initial examination to determine IMA, white blood cell (WBC) and C‐reactive protein (CRP) values. Results Mean IMA values of patients with acute appendicitis (AA), perforated appendicitis (PA) and non‐specific abdominal pain were significantly higher compared to the control group. Mean IMA values of the AA and PA cases were also significantly higher compared to the group with non‐specific abdominal pain. No significant difference was determined in mean IMA between the AA and PA groups. WBC and CRP levels of the AA and PA groups were significantly higher compared to the group with non‐specific abdominal pain. Conclusion Our study shows that IMA, together with WBC and CRP, may be a biomarker capable of assisting the differential diagnosis of acute abdominal pain in children and distinguishing surgical from non‐surgical cases.