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Near final height in patients with idiopathic growth hormone deficiency: A single‐centre experience
Author(s) -
Kurnaz Erdal,
Çetinkaya Semra,
Aycan Zehra
Publication year - 2018
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.14061
Subject(s) - ighd , medicine , growth hormone deficiency , reference range , growth hormone , pediatrics , endocrinology , hormone , gastroenterology
Aim We analysed near final height (NFH) data in children with growth hormone deficiency (GHD) treated with recombinant human GH (rhGH). Methods We divided the idiopathic GHD patients into two groups, isolated GHD (IGHD) and multiple pituitary hormone deficiency, to evaluate NFH. Then, data were grouped according to gender, pre‐pubertal/pubertal status and spontaneous or induced puberty. The trial was performed as a retrospective study. Median values are given, and measurements are expressed as standard deviation scores (SDSs). Results rhGH therapy was started at a median age of 12.1 (range 9.1–14.9) years in the IGHD group ( n = 162, 83 males) and 9.1 (range 4.9–13.4) years in the multiple pituitary hormone deficiency group ( n = 33, 22 males) at a median dose of 0.20 mg/kg/week. Height SDSs at the onset of therapy were −3.2 (range −4.4 to −2.6) and −3.9 (−6.8 to −2.8) in the two groups, respectively ( P < 0.001). NFH SDSs were −1.8 (−2.9 to −1) and −1.6 (−3.1 to −0.4) ( P = 0.139), and delta height SDSs (finish – start) were 1.4 (0.3–2.5) and 2.6 (1.5–4.6) ( P < 0.001), respectively. Total delta height was 1.4 SDS (0.4–3.1) in patients who started rhGH treatment in the pre‐pubertal period and 1.3 SDS (0.3–2.4) ( P = 0.106) in those who started rhGH in the pubertal period. Conclusions About 85% of the cases reached their genetic height potential. Delta height SDSs were higher than expected in cases that started treatment during the pubertal period. Therefore, it is possible to achieve NFH within the mid‐parental height range in patients who start therapy during puberty.