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Risk of cerebral palsy in Chinese children: A N:M matched case control study
Author(s) -
Gao Jing,
Zhao Bin,
He Luna,
Sun Meiling,
Yu Xuefeng,
Wang Lina
Publication year - 2017
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.13479
Subject(s) - medicine , odds ratio , confidence interval , logistic regression , case control study , childbirth , cerebral palsy , pregnancy , univariate analysis , incidence (geometry) , epidemiology , obstetrics , multivariate analysis , pediatrics , physical therapy , genetics , physics , optics , biology
Aim To estimate epidemiological risk factors for cerebral palsy (CP) in children. Methods A N:M matched case control study was conducted in 114 persons with CP and 1286 controls. Relevant data were collected using a maternal self‐design questionnaire. Univariate logistic regression and multivariate conditional logistic regression analyses were performed using SPSS. Results Univariate analysis has yielded 20 significant risk factors for CP. Advanced maternal age (30 years or older) at childbirth (adjusted odds ratio (OR) 1.63, 95% confidence interval (CI) 0.98–2.72), alcohol consumption during pregnancy (adjusted OR 4.17, 95% CI 1.23–14.08), living in the countryside (adjusted OR 1.71, 95% CI 1.18–2.48), father's occupational exposure to harmful substances (adjusted OR 3.34, 95% CI 1.61–6.93) and multiple births (adjusted OR 3.10, 95% CI 1.65–5.84) were found to be risk factors for CP by multivariate analysis. On the other side, high mother's education level (adjusted OR 0.60, 95% CI 0.46–0.76), folic acid supplements (adjusted OR 0.50, 95% CI 0.30–0.82), and high birth hospital level (adjusted OR 0.68, 95% CI 0.52–0.90) were found to be protective factors. Conclusion Although the important risk factors of CP focus on gestation at birth and perinatal events, the incidence could probably be further lowered, if potential risk factors identified in this study are considered.