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Nasal bi‐level positive airway pressure (BiPAP) versus nasal continuous positive airway pressure (CPAP) in preterm infants ≤32 weeks: A retrospective cohort study
Author(s) -
Rong ZhiHui,
Li WenBin,
Liu Wei,
Cai BaoHuan,
Wang Jing,
Yang Min,
Li Wei,
Chang LiWen
Publication year - 2016
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.13175
Subject(s) - medicine , continuous positive airway pressure , bronchopulmonary dysplasia , positive airway pressure , neonatal intensive care unit , cohort , retrospective cohort study , intubation , incidence (geometry) , pediatrics , airway , intensive care , intensive care unit , cohort study , gestational age , anesthesia , surgery , intensive care medicine , obstructive sleep apnea , pregnancy , physics , optics , biology , genetics
Aim To investigate whether Bi‐level positive airway pressure (BiPAP), compared with nasal continuous positive airway pressure (CPAP), is a more effective therapeutic strategy in preterm infants ≤32 weeks. Methods All inborn infants between 26 +1 and 32 +6 weeks' gestation, admitted to the neonatal intensive care unit (NICU ) of Tongji Medical Hospital between 1 January, 2010 and 31 December, 2011 (the 2010–2011 cohort or CPAP cohort) and between 1 January, 2012 and 31 December, 2013 (the 2012–2013 cohort or BiPAP cohort), were retrospectively identified. The primary outcome was intubation in infants < 72 h of age; secondary outcomes were mortality and the incidence of bronchopulmonary dysplasia (BPD). Results There were 213 in the 2010–2011 cohort and 243 infants in the 2012–2013 cohort. There were fewer infants intubated within the first 72 h of age in the 2012–2013 cohort than in the 2010–2011 cohort (15% vs. 23%, P < 0.05). Of the infants who received some form of positive airway pressure, 12/94 (13%) of infants on BiPAP versus 23/74 (31%) on CPAP were subsequently intubated ( P < 0.01). There was no difference in the incidence of moderate and severe BPD between the two groups (7% vs. 8%, P =0.52). Conclusions In this retrospective cohort study, we found BiPAP, compared with CPAP, reduced the need for intubation within the first 72 h of age.