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Fulminant liver failure in a neonate
Author(s) -
Clarke Naomi E,
Gilby Damien,
Savoia Helen,
Oliver Mark R,
Rogerson Sheryle
Publication year - 2016
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.13090
Subject(s) - medicine , fulminant , liver transplantation , liver disease , fulminant hepatic failure , disease , pediatrics , pregnancy , gestational age , liver injury , transplantation , biology , genetics
Neonatal acute liver disease is relatively rare, with multiple different aetiologies including congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. We report a case of neonatal liver failure in a preterm, growth‐restricted infant, who underwent extensive investigation and was clinically diagnosed with gestational alloimmune liver disease, which was confirmed on post‐mortem examination. We then discuss management of neonatal liver failure and gestational alloimmune liver disease, including maternal management in future pregnancies.