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I nterleukin‐4 polymorphism is associated with severity of respiratory syncytial virus infection
Author(s) -
Zhang Mingzhi,
Lu Yong,
Zhang Xiaobo,
Lu Aizhen,
Wang Libo,
Chen Chao
Publication year - 2016
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12985
Subject(s) - bronchiolitis , medicine , respiratory system , haplotype , virus , single nucleotide polymorphism , immunology , gastroenterology , genotype , gene , biology , biochemistry
Aim Respiratory syncytial virus ( RSV ) infection is a major health problem in young children. This study aimed to investigate whether the interleukin ( IL )‐4 −590 C/T and −33 C/T polymorphisms were associated with the susceptibility to RSV infection in Chinese Han children and with the severity of the infection. Methods The IL ‐4 −590 C/T and −33 C/T SNPs were evaluated in 218 inpatients with RSV bronchiolitis and 303 healthy controls. The severity of RSV bronchiolitis was evaluated using a respiratory scoring system. Results The frequencies of IL ‐4 −590 CC , CT and TT in the 218 RSV bronchiolitis patients versus the 303 controls were 1.4% versus 1.7%, 21.1% versus 34% and 77.5% versus 64.4%, respectively. The frequencies of IL ‐4 −33 CC , CT and TT were 1.4%, 20.6% and 78%, respectively, in RSV bronchiolitis patients and 2.3%, 35.6% and 62%, respectively, in the controls. The frequencies of the IL ‐4 −590 C/T and −33 C/T polymorphisms were significantly different between the two groups. There was a significant difference in the frequency of the T‐T haplotype formed by −590 C/T and −33C /T between the two groups. The respiratory score of the RSV bronchiolitis cases with −590TT was 3.02 ± 0.44, which was significantly higher than those with −590CT (2.80 ± 0.44). The score for patients with −33TT was 3.03 ± 0.43, which was significantly higher than the score of 2.78 ± 0.46 for patients with −33CT. Conclusions In Chinese Han children, the IL ‐4 −590 C/T and −33 C/T polymorphisms were associated with the susceptibility to RSV and the severity of the infection.