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Low vitamin D is associated with hypertension in paediatric obesity
Author(s) -
Kao KungTing,
Abidi Nobia,
Ranasinha Sanjeeva,
Brown Justin,
Rodda Christine,
McCallum Zoe,
Zacharin Margaret,
Simm Peter J,
Magnussen Costan G,
Sabin Matthew A
Publication year - 2015
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12935
Subject(s) - medicine , vitamin d and neurology , blood pressure , body mass index , overweight , obesity , population , vitamin d deficiency , endocrinology , environmental health
Aim The aim of this paper was to investigate the relationship between circulating 25‐hydroxyvitamin D (25( OH )D) and cardio‐metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. Methods We conducted a retrospective cross‐sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in M elbourne, A ustralia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25( OH ) D , glucose, insulin, cholesterol, triglyceride, high‐density lipoprotein, liver function, calcium and phosphate. Results 25( OH ) D data were available in 229 patients (age 3–18 years; 116 men; mean (standard deviation) body mass index ( BMI ) Z ‐score 2.5 (0.5) ). One hundred four (45%) participants were 25( OH ) D deficient (<50 nmol/ L ). Lower serum 25( OH ) D levels were associated with higher BMI Z‐score ( P ‐trend = 0.001), total fat mass ( P ‐trend = 0.009), systolic ( P ‐trend = 0.03) and diastolic blood pressures( P ‐trend = 0.009). In multivariable‐adjusted regression analysis, 25( OH ) D was significantly lower in those with elevated blood pressure after adjustment for BMI ( P ‐trend = 0.004) or total fat mass ( P ‐trend = 0.01). Conclusion Overweight and obese youth attending specialist obesity services have a high prevalence of vitamin D deficiency. In this population, lower levels of vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.