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Oesophageal atresia and tracheo‐oesophageal fistula in W estern A ustralia: Prevalence and trends
Author(s) -
Leoncini Emanuele,
Bower Carol,
Nassar Natasha
Publication year - 2015
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12909
Subject(s) - medicine , population , pediatrics , prevalence , tracheoesophageal fistula , atresia , pregnancy , prenatal diagnosis , fistula , epidemiology , obstetrics , fetus , surgery , environmental health , biology , genetics
Aim A recent international study reported a higher prevalence of oesophageal atresia with or without tracheo‐oesophageal fistula ( OA ± TOF ) in Western A ustralia ( WA ). The aim of this study was to examine the prevalence and trends of OA and/or TOF in WA , determine the proportion of cases with associated anomalies and explore the impact of time of diagnosis. Methods The study population comprised all infants born in WA , 1980–2009, and registered with OA and/or TOF on the WA Register of Developmental Anomalies ( WARDA ). Results OA ± TOF and TOF alone affect, on average, one in every 2927 births in WA , with a total prevalence of 3.00 and 0.42 per 10 000 births, respectively. The prevalence of OA ± TOF increased by 2.0% per annum, with only cases with associated anomalies (64% of cases) demonstrating an increase. TOF rates were stable. Among OA ± TOF infants, the proportion of live births, stillbirths and elective terminations of pregnancy for fetal anomaly ( TOPFA ) was 79%, 6% and 15%, respectively, whereas the majority (94%) of TOF only cases were live births. In 2000–2009, there was 30% fall in OA ± TOF live births with 61 (58%) cases diagnosed in first week of life, 10 (9%) prenatally and 34 (32%) at post‐mortem only. Conclusions A higher prevalence of OA ± TOF in WA was observed with increase over time attributable to increase with associated anomalies. Consistent reporting, availability of prenatal diagnosis and ascertainment of cases following TOPFA or post‐mortem examinations can significantly affect prevalence of OA and/or TOF .