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Congenital cytomegalovirus infection is a significant cause of moderate to profound sensorineural hearing loss in Q ueensland children
Author(s) -
Toumpas Christopher J,
Clark Julia,
Harris Alison,
Beswick Rachael,
Nourse Clare B
Publication year - 2015
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12776
Subject(s) - medicine , hearing loss , cytomegalovirus , pediatrics , referral , retrospective cohort study , audiology , sensorineural hearing loss , newborn screening , surgery , viral disease , herpesviridae , human immunodeficiency virus (hiv) , immunology , family medicine
Aim To investigate the proportion of children with moderate to profound hearing loss who have congenital cytomegalovirus ( cCMV ) infection. Method Retrospective analysis of CMV dried blood spot ( DBS ) polymerase chain reaction ( PCR ) in children with moderate to profound hearing impairment referred to tertiary referral centres in Q ueensland. Participants were under 18 years old with no readily identified cause of hearing impairment, between 2008 and 2011. The primary outcome measure was DBS CMV PCR . Other outcome measures for cases referred to the C hildhood H earing C linic ( CHC ) at the M ater C hildren's H ospital were level of hearing impairment and the neonatal hearing screen result. Results Of DBS CMV PCR testing for 106 children at the CHC for 2008 to 2011 inclusive, nine (8.5%) were positive (five with bilateral hearing impairment, four with unilateral hearing impairment). The prevalence of cCMV infection in children with moderate to profound hearing impairment was 8.4%, consistent with the statewide rate of 9.4% for 2008 to mid‐2011. Conclusion cCMV is a significant cause of hearing impairment in Q ueensland children. Investigation for cCMV by retrospective DBS CMV PCR should be part of the routine investigation of all babies and young children with hearing impairment. However early diagnosis is preferable and could be achieved by routine early screening of all newborns with hearing impairment for CMV before 3 weeks of age. The healthy hearing screening programme is a routine part of neonatal care. Enhancing the integration of screening for cCMV may reduce the current delays in diagnosis and should be evaluated.