Oral vitamin B 12 treatment is effective for children with nutritional vitamin B 12 deficiency

Aim Despite being one of common preventable deficiency disorders, vitamin B12 (vit‐ B 12) deficiency can lead to serious health problems both in children and adult. The familiar treatment through parenteral route for vit‐ B 12 deficiency frequently leads to poor adherence, and adequate response to treatment has lead to interest in oral supplementation. This study investigates the efficacy of oral vit‐ B 12 treatment in children with nutritional vit‐ B 12 deficiency. Methods Forty‐seven children (from 1 month to 17 years) with vit‐ B 12 levels below 200 pg/mL were allocated either of two study groups: Group 1 (1–20 months) and Group 2 (6–17 years) which were subdivided according to the duration of treatment (Group 1A&2A: 4 months; Group 1B&2B: 8 months of 1000 μg oral vit‐ B 12, every day for a week, every other day for 2 weeks, 2 days a week for 2 weeks, then once a week). Results Vit‐ B 12 levels among all groups were significantly restored following high oral vit‐ B 12 doses ( P = 0.013, P = 0.001), the regimen being more effective in Group1A and Group1B. Correlation analysis of serum vit‐ B 12 levels and age at the end of treatment revealed a decreasing trend with the increasing patient age (corelation respectively −65.2%, P = 0.08; −35.4%; P = 0.25). Conclusion Data from this study indicate that oral vit‐ B 12 (1000 μg) for 4 months is effective, giving clinicians more choice, for treatment of children with nutritional vit‐ B 12 deficiency. However, despite this high dose, lower levels were achieved in older children indicating the necessity of dosage adjustment in accordance with body weight.