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Cholangitis in children with biliary atresia: Health‐care resource utilisation
Author(s) -
Lee Jie Ying,
Lim Leon Tak Keet,
Quak Seng Hock,
Prabhakaran Krishnan,
Aw Marion
Publication year - 2014
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12463
Subject(s) - medicine , biliary atresia , incidence (geometry) , pediatrics , complication , liver transplantation , transplantation , physics , optics
Aim Cholangitis is a well‐known complication that contributes to morbidity, mortality, as well as health‐care utilisation in children with biliary atresia who have undergone the K asai portoenterostomy. The aim of the study was to determine the common causative organisms for cholangitis and characterise its burden, health‐care resource and service utilisation and cost. Methods This was a retrospective chart review of children who underwent K asai portoenterostomy in our institution from 1988 to 2011. The causative organisms were identified based on culture reports. The burden of the disease was estimated based on the number of patients experiencing one or more episodes of cholangitis. Health‐care resource and service utilisation were based on different categories, and cost was computed based on the charges at the institution. Results Twenty‐seven (64.3%) out of 42 children included in the analysis experienced at least one episode of cholangitis. There were a total of 97 episodes of cholangitis, with an average of 3.6 (1–15) episodes per patient. The average length of stay per episode of cholangitis was 14.8 (2–64) days. Common organisms isolated during blood cultures were K lebsiella pneumoniae , E nterococcus , E scherichia coli and P seudomonas aeruginosa . The estimated cost per in‐patient admission of 15 days (rounded off) for a single episode of cholangitis was $SG 8986.61 ( $US 7369.02). Conclusion The knowledge about the incidence and cost of cholangitis will allow physicians to counsel parents of children newly diagnosed with biliary atresia and to better prepare them both emotionally and financially for what to expect.