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Genetic and clinical contributions to cerebral palsy: A multi‐variable analysis
Author(s) -
O'Callaghan Michael E,
MacLennan Alastair H,
Gibson Catherine S,
McMichael Gai L,
Haan Eric A,
Broadbent Jessica L,
Baghurst Peter A,
Goldwater Paul N,
Dekker Gustaaf A
Publication year - 2013
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12279
Subject(s) - cerebral palsy , medicine , odds ratio , snp , single nucleotide polymorphism , confounding , confidence interval , pregnancy , pediatrics , obstetrics , genetics , biology , physical therapy , genotype , gene
Aim This study aims to examine single nucleotide polymorphism ( SNP ) associations with cerebral palsy in a multi‐variable analysis adjusting for potential clinical confounders and to assess SNP – SNP and SNP –maternal infection interactions as contributors to cerebral palsy. Methods A case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty‐nine candidate SNP s were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases. Results Both maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38–0.79; odds ratio 0.57, 95% confidence interval 0.4–0.82, respectively). Analysis did not show any statistically significant SNP – SNP or SNP –maternal infection interactions after correction for multiple testing. Conclusions Maternal and child inducible nitric oxide synthase SNP s are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP – SNP or SNP –maternal infection interactions as modulators of cerebral palsy risk.