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Glucose‐6‐phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experıence
Author(s) -
Çelik H Tolga,
Günbey Ceren,
Ünal Şule,
Gümrük Fatma,
Yurdakök Murat
Publication year - 2013
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/jpc.12193
Subject(s) - medicine , jaundice , exchange transfusion , incidence (geometry) , pediatrics , glucose 6 phosphate dehydrogenase deficiency , glucosephosphate dehydrogenase deficiency , bilirubin , glucose 6 phosphate dehydrogenase , serum bilirubin , dehydrogenase , enzyme , biochemistry , chemistry , physics , optics
Aim The aim of this study was to investigate the prevalence of glucose‐6‐phospate dehydrogenase ( G 6 PD ) deficiency in newborn infants with neonatal hyperbilirubinaemia and to compare the clinical features of G 6 PD ‐deficient and G 6 PD ‐normal newborn infants. Methods A total of 4906 term and preterm neonates with indirect hyperbilirubinaemia were retrospectively evaluated according to demographic, neonatal features, bilirubin levels, erythrocyte G 6 PD levels, other risk factors and treatments. Results Among 4906 newborn infants with indirect hyperbilirubinaemia, 55 (1.12%) neonates were G 6 PD ‐deficient. In our study, no statistically significant difference was detected between G 6 PD ‐deficient and G 6 PD ‐normal infants in relation to the time of onset of jaundice, bilirubin levels and duration of phototherapy. However, the incidence of exchange transfusion in G 6 PD ‐deficient infants was 16.4% while it was only 3.3% in G 6 PD normal infants ( P < 0.05). Conclusion Testing for G 6P D must be ordered to all newborns who are receiving phototherapy and especially to those who are coming from the high incident geographical regions and less responsive to phototherapy.

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