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Evaluation of renal function in a specific population of living kidney donors
Author(s) -
de Souza Rodrigues Thalyta,
Amorim de Albuquerque Ana Letícia,
de Oliveira Cosme Fillipe Agra,
de Oliveira José Ayrton Macedo Guimarães,
Magalhães Indalécio,
Teles Flávio,
Pedrosa André Falcão
Publication year - 2017
Publication title -
journal of renal care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.381
H-Index - 27
eISSN - 1755-6686
pISSN - 1755-6678
DOI - 10.1111/jorc.12198
Subject(s) - medicine , microalbuminuria , renal function , creatinine , body mass index , nephrectomy , urology , kidney transplantation , kidney , anthropometry , population , environmental health
SUMMARY Background The increase in candidates for kidney transplant has led to growth in the number of living donor transplants. Therefore, studies that adequately evaluate the possible long‐term consequences of elective transplant nephrectomy are needed. Objective To evaluate the possible long‐term adverse effects of transplant nephrectomy on the renal function of living kidney donors. Design A cross‐sectional study. Participants Thirty‐three living kidney donors registered in the transplant programme of a centre in Alagoas, Brazil. Measurements Demographic characteristics, anthropometric measures, clinical data and biomarkers (creatinine, eGFR, microalbuminuria, cholesterol and triglycerides) were measured. Creatinine clearance was calculated using the Cockcroft‐Gault and Modification of Diet in Renal Disease formulae. Results Of the 33 individuals, 63.63% were female, and the median age was 45 years. Additionally, 24.24% of these individuals had altered blood pressure, 39.39% had altered abdominal circumference (AC) and 36.36% were obese, with a body mass index ≥30. Furthermore, 33.33% of these individuals had elevated triglyceride levels. The average eGFR was 97.33 (33.03–175.9) ml/min/1.73 m 2 (CG) and 84.14 (29.4–131) ml/min/1.73 m 2 (MDRD). The microalbuminuria level was altered in 12.12% patients. Conclusion Kidney donation is unquestionably a safe procedure. However, a better understanding of the long‐term consequences of living donor kidney transplantation is still needed. This knowledge may have important implications for the follow‐up of these patients. Our study has demonstrated a non‐negligible presence of an early marker of glomerular injury and a decrease in the GFR of some patients, thereby reinforcing the proposal for long‐term follow‐up of living kidney donors.