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Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers
Author(s) -
Trucco Elisa M.,
Cope Lora M.,
Burmeister Margit,
Zucker Robert A.,
Heitzeg Mary M.
Publication year - 2018
Publication title -
journal of research on adolescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.342
H-Index - 95
eISSN - 1532-7795
pISSN - 1050-8392
DOI - 10.1111/jora.12341
Subject(s) - psychology , temperament , functional magnetic resonance imaging , angular gyrus , inferior frontal gyrus , parietal lobe , neural correlates of consciousness , middle frontal gyrus , neuroscience , developmental psychology , personality , cognition , social psychology
Neural and temperamental mechanisms through which a genetic risk marker in the γ‐amino butyric acid α2 receptor subunit ( GABRA 2 ) impacts adolescent functioning were investigated. Participants ( N = 80; 29 female) completed an emotional word task during functional magnetic resonance imaging. Behavioral control, negative emotionality, and resiliency temperament constructs were assessed. Externalizing and internalizing problems were the outcomes. Those with the GABRA 2 minor allele had reduced activation to positive words in the angular gyrus, middle temporal gyrus, and cerebellum, and to negative words in frontal, parietal, and occipital cortices. Reduced activation in the angular gyrus predicted greater negative emotionality and, in turn, elevated externalizing problems. Reduced activation in the inferior parietal cortex predicted greater resiliency and, in turn, low externalizing problems.