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Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners
Author(s) -
Neppelenbroek Karin Hermana,
Lima Jozely Francisca Mello,
Hotta Juliana,
Galitesi Lucas Lulo,
Almeida Ana Lucia Pompéia Fraga,
Urban Vanessa Migliorini
Publication year - 2018
Publication title -
journal of prosthodontics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.902
H-Index - 60
eISSN - 1532-849X
pISSN - 1059-941X
DOI - 10.1111/jopr.12660
Subject(s) - ultimate tensile strength , miconazole , chlorhexidine , nystatin , candida albicans , itraconazole , distilled water , ketoconazole , chemistry , elongation , microbiology and biotechnology , materials science , antifungal , dentistry , medicine , biology , composite material , chromatography
Purpose To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research. Materials and Methods Dumbbell‐shaped specimens (n = 7) with a central cross‐sectional area of 6 × 3 × 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0.032 g), chlorhexidine diacetate (0.064 g), ketoconazole (0.128 g), miconazole (0.256 g), and itraconazole (0.256 g). After plasticization, specimens were immersed in distilled water at 37°C for 24 hours, 7 or 14 days, and then tested in tension in a universal testing machine at 40 mm/min. Data of tensile strength (MPa) and elongation percentage (%) were submitted to 3‐way ANOVA and Tukey's test (α = 0.05). Results At the end of 14 days, the tensile strength for both materials was significantly lower in the groups modified by miconazole and itraconazole compared to the other groups ( p < 0.0001), which showed no significant difference between them ( p > 0.05). After 7 and 14 days in water, miconazole and itraconazole added into both materials resulted in significantly lower elongation percentages compared to the other antifungal agents and control ( p < 0.0001), which were similar to each other ( p > 0.05). Conclusions The addition of the nystatin, chlorhexidine, and ketoconazole at MICs for C. albicans biofilm resulted in no harmful effects on the tensile strength and elongation percentage of the temporary soft denture liner materials up to 14 days.