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Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update
Author(s) -
Wagner Vivian Petersen,
RodriguesFernandes Carla Isabelly,
Carvalho Marcus Vinícius Ribeiro,
Santos Jean Nunes,
Barra Marinez Bizarro,
Hunter Keith D.,
AguirreUrizar Jose Manuel,
Heerden Willie F. P.,
Vargas Pablo Agustin,
Fonseca Felipe Paiva,
Martins Manoela Domingues
Publication year - 2021
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.13214
Subject(s) - malt lymphoma , mantle cell lymphoma , medicine , lymphoma , follicular lymphoma , chronic lymphocytic leukemia , pathology , marginal zone b cell lymphoma , mucosa associated lymphoid tissue , marginal zone , b cell , leukemia , immunology , antibody
Abstract Background Although uncommon, mature small B‐cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. In this manuscript, we attempted to integrate the currently available data on the clinicopathological features of follicular lymphoma (FL), mantle cell lymphoma (MCL), extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT‐L), and chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) affecting these anatomical regions. Methods An updated descriptive literature review was carried out and a detailed electronic search was done in multiple databases to gather all cases affecting the oral/maxillofacial region and palatine tonsils. Results We observed that MALT‐L was the most frequently reported subtype, followed by FL, MCL, and CLL/SLL. The palate was affected in a high proportion of cases and the most usual clinical presentation was an asymptomatic swelling. MALT‐L and CLL/SLL neoplastic cells were strongly associated with small salivary glands. FL showed no gender preference, while MCL and CLL/SLL were more prevalent in males and MALT‐L in females. Overall, cases were more common in elderly individuals. Patients’ treatment and outcome varied, with MCL being the most aggressive neoplasm with a dismal prognosis in comparison to FL and MALT‐L. Conclusion Despite the poor documentation in many of the cases available, especially regarding the microscopic and molecular features of tumors, this review demonstrated that the oral mature small B‐cell lymphomas investigated share similar clinical presentation, but carry different prognostic significance, demanding an accurate diagnosis.