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Burkitt lymphoma of the head and neck: An international collaborative study
Author(s) -
Arboleda Lady Paola Aristizabal,
RodriguesFernandes Carla Isabelly,
Mariz Bruno Augusto Linhares Almeida,
Andrade Bruno Augusto Benevenuto,
Abrahão Aline Corrêa,
Agostini Michelle,
Romañach Mário José,
Pontes Hélder Antônio Rebelo,
Fonseca Felipe Paiva,
Robinson Liam,
Heerden Willie F. P.,
Carlos Román,
Tager Elena María José Román,
Hoffmann Iva Loureiro,
Cardinalli Izilda Aparecida,
Mendonça Regina Maria Holanda,
Vasconcelos Carvalho Marianne,
MartinsdeBarros Allan Vinícius,
Rocha André Caroli,
Khurram Syed Ali,
Speight Paul M.,
Lopes Marcio Ajudarte,
Vargas Pablo Agustin,
Almeida Oslei Paes,
SantosSilva Alan Roger
Publication year - 2021
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.13209
Subject(s) - medicine , lymphoma , bcl6 , cervical lymphadenopathy , cervical lymph nodes , tonsil , immunohistochemistry , epidemiology , pathology , b cell , metastasis , germinal center , antibody , disease , immunology , cancer
Abstract Background Burkitt lymphoma (BL) is an aggressive B‐cell lymphoma with three variants (endemic, sporadic, and immunodeficiency‐associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein‐Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1‐39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c‐Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki‐67 index ranged from 90 to 100%. Conclusion The clinicopathological and EBV profile of BLHN in South African, Guatemalan, and Brazilian patients is similar.