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Prevalence and concordance of oral HPV infections with cervical HPV infections in women referred to colposcopy with abnormal cytology
Author(s) -
Tewari Prerna,
Banka Prakashini,
Kernan Niamh,
Reynolds Stephen,
White Christine,
Pilkington Loretto,
O’Toole Sharon,
Sharp Linda,
D’Arcy Tom,
Murphy Cliona,
Comiskey Catherine,
Martin Cara M.,
O’Leary John J.
Publication year - 2021
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.13172
Subject(s) - medicine , concordance , colposcopy , genotyping , hpv infection , concomitant , gynecology , obstetrics , population , cervical cancer , genotype , cancer , biology , biochemistry , environmental health , gene
Background Considering the shared aetiology of Human Papillomavirus infections in oropharyngeal and cervical cancers and the possible role for sexual transmission, several key aspects of the relationship between cervical and oral infections merit investigation, including prevalence of concomitant oral HPV infection and type‐specific concordance with concurrent cervical infections. Methods A cross‐section study was performed on women referred to colposcopy clinics with cytological abnormalities and a cervical HPV infection. An oral rinse sample was taken from the participants at their baseline visit for HPV testing, and a demographic and risk factor questionnaire was also administered. HPV DNA testing was carried out on the Cobas 4800 platform and extended genotyping was carried out with the INNO‐LiPA HPV Genotyping Extra II assay. HPV genotyping was also carried out on the concurrent cervical tissue samples on all women who had a positive oral HPV infection. Results The prevalence of oral HPV infections was 10.0% (95%CI:5.9–13.7) in the study population. HPV18 was the most frequent genotype (7.0%). Concordant oral and cervical HPV infections were detected in 28.6% of women. Age ( p = 0.005) and level of education ( p = 0.02) were significantly associated with a prevalent oral HPV infection. Conclusion Concomitant oral HPV infections were present in 10.0% of women referred to colposcopy with a pre‐existing cervical HPV infections and cytological abnormalities. Although mild type‐specific concordance was observed between oral and cervical HPV infections, findings suggest that infections at these sites may not be independent of each other.