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Prognostic and clinicopathological significance of podoplanin immunoexpression in oral and oropharyngeal squamous cell carcinoma: A systematic review
Author(s) -
Mello Fernanda Weber,
Kammer Pedro Vitali,
Silva Carolina Amália Barcellos,
Parkinson Eric Kenneth,
Monteiro Luís,
Warnakulasuriya Saman,
Rivero Elena Riet Correa
Publication year - 2021
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.13041
Subject(s) - podoplanin , medicine , oncology , immunohistochemistry , lymph node , stage (stratigraphy) , pathology , basal cell , cancer , clinical significance , biology , paleontology
Background Podoplanin (PDPN) is a glycoprotein associated with epithelial‐mesenchymal transition, invasion, and metastasis in several types of malignancies, including oral and oropharyngeal squamous cell carcinoma (OSCC). The aim of this systematic review (SR) was to summarize and critically appraise the available evidence about the association between PDPN immunoexpression and clinicopathological features and its utility as a prognostic marker in OSCC. Methods Five electronic databases and three gray literature databases were searched for immunohistochemical studies, which were selected in a two‐phase process. Results From 721 records identified, 22 cohort and seven analytical cross‐sectional studies were included. Few studies reported that PDPN expression was associated with poorer survival rates in OSCC: overall survival = 4/12, disease‐free survival = 4/7, and cancer‐specific survival = 2/4 studies. Positive associations were most frequently reported on lymph node involvement, higher histopathological grade, and advanced clinical stages. Conclusion Within limitations of this SR, PDPN may be associated with lymph node involvement, histopathological grade, and clinical stage of OSCC. Current evidence suggests that PDPN could be a useful prognostic marker for OSCC that needs further exploration.