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The prognostic role of tumour‐infiltrating lymphocytes in oral squamous cell carcinoma: A meta‐analysis
Author(s) -
Huang Zhengxian,
Xie Nan,
Liu Haichao,
Wan Yuehan,
Zhu Yue,
Zhang Ming,
Tao Yifan,
Zhou Han,
Liu Xiqiang,
Hou Jinsong,
Wang Cheng
Publication year - 2019
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12927
Subject(s) - tumor infiltrating lymphocytes , cd68 , cd163 , medicine , cd8 , meta analysis , tumor microenvironment , infiltration (hvac) , pathology , basal cell , oncology , immune system , immunohistochemistry , immunology , macrophage , biology , biochemistry , physics , in vitro , thermodynamics
It has been suggested that tumour‐infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta‐analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta‐analysis. Our pooled meta‐analysis showed that high infiltration of CD8 + TILs, CD45RO + TILs and CD57 + TILs favoured better overall survival (OS). However, high infiltration of CD68 + macrophages and CD163 + macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8 + TILs, CD45RO + TILs, CD57 + TILs, CD68 + macrophages and CD163 + macrophages might serve as novel prognostic factors and therapeutic targets in OSCC.