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MiR‐455‐3p, miR‐150 and miR‐375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma
Author(s) -
Brown Amy L.,
AlSamadi Ahmed,
Sperandio Marcelo,
Soares Andresa Borges,
Teixeira Lucas Novaes,
Martinez Elizabeth F.,
Demasi Ana Paula Dias,
Araújo Vera Cavalcanti,
Leivo Ilmo,
Salo Tuula,
PassadorSantos Fabricio
Publication year - 2019
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12894
Subject(s) - adenoid cystic carcinoma , antibody dependent cell mediated cytotoxicity , salivary gland , microrna , adenocarcinoma , adenoid , cancer research , pathology , biology , salivary gland cancer , carcinoma , medicine , gene , immunology , cancer , genetics , antibody , monoclonal antibody
Background Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical and histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) are short, non‐coding RNA sequences of 19‐25 nucleotides in length that are involved in post‐transcriptional protein expression. They have been shown to play important roles in neoplastic and non‐neoplastic processes and have been suggested as diagnostic and prognostic markers. Methods This study, using quantitative RT‐PCR, investigated miR‐150, miR‐455‐3p and miR‐375 expression, in order to identify a possible molecular distinction between AdCC and PAC. Results miRNA‐150 and miRNA‐375 expression was significantly decreased in AdCC and PAC compared with salivary gland tissue controls, whilst miRNA‐455‐3p showed significantly increased expression in AdCC when compared to PAC, ( P < 0.05). miR‐150, miR‐357 and miR‐455‐3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) ( P > 0.05). Conclusion MiR‐455‐3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases.