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Association of nitric oxide with oral lichen planus
Author(s) -
Alamir Abdul Wahab H.,
Arakeri Gururaj,
Patil Shankargouda,
Awan Kamran Habib,
Kujan Omar,
Aljabab Abdulsalam,
Fonseca Felipe,
Brennan Peter A.
Publication year - 2019
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12837
Subject(s) - oral lichen planus , nitric oxide , etiology , medicine , pathogenesis , meta analysis , dermatology , case control study , association (psychology) , psychology , psychotherapist
Background The small signalling molecule nitric oxide ( NO ) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus ( OLP ). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP . Methods The focused question being addressed was “ Is there an association between nitric oxide and OLP ?” PubMed, EMBASE , Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria. Results Seven studies that met the eligibility criteria were included. All of these were case‐control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non‐erosive OLP . Conclusion These findings support that an association exists between higher NO concentration and OLP . However, larger high‐quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP .