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Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma
Author(s) -
Díaz Katya Pulido,
Gondak Rogério,
Martins Leandro Liporoni,
Almeida Oslei Paes,
León Jorge Esquiche,
Mariano Fernanda Viviane,
Altemani Albina,
Vargas Pablo Agustin
Publication year - 2019
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12820
Subject(s) - myoepithelial cell , fatty acid synthase , carcinoma ex pleomorphic adenoma , immunohistochemistry , pathology , malignant transformation , adenoma , pleomorphic adenoma , carcinoma , fatty acid synthesis , biology , lipid metabolism , cancer research , medicine , salivary gland , fatty acid , endocrinology , biochemistry
Background Fatty acid synthase ( FASN ) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma ( CXPA s) and 25 pleomorphic adenomas ( PA s). Results Ki‐67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA ( P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPA s, and these malignant areas also had intense nuclear immunoreactivity for Ki‐67. Conclusions The present results suggest that overexpression of FASN in CXPA s might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA . FASN associated with Ki‐67 may be useful diagnostic markers for CXPA .