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PTEN and miR‐26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma
Author(s) -
Baghaei Fereshteh,
Abdollahi Alireza,
Mohammadpour Hadiseh,
Jahanbin Mahsa,
Naseri Taheri Fatemeh,
Aminishakib Pouyan,
Emami Razavi Amirnader,
Kharazifard Mohamadjavad
Publication year - 2019
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12794
Subject(s) - pten , malignancy , cancer research , biology , tumor progression , microrna , stage (stratigraphy) , basal cell , phosphatase , carcinoma , pathology , cancer , gene , medicine , apoptosis , phosphorylation , microbiology and biotechnology , genetics , pi3k/akt/mtor pathway , paleontology
Backgrounds Oral Squamous Cell Carcinoma ( OSCC ) is the most common malignancy of the oral cavity. Phosphatase and TEN sin homolog ( PTEN ) is a well‐known tumor suppressive gene regulated by several biomarkers including a small single‐stranded molecule, micro RNA 26b (miR‐26b). Here, we studied the expression of PTEN and miR‐26b in OSCC specimens in comparison with adjacent normal mucosa. Methods The expressions of PTEN and miR‐26b genes were evaluated at mRNA level in OSCC and adjacent normal fresh frozen tissues in 49 patients using Quantitative Real‐Time PCR and analyzed their associations with clinicopathological factors. Results The expression level of PTEN was significantly lower in OSCC specimens comparing with adjacent normal tissues ( P ‐value = 0.000). The expression of PTEN was associated with T stage ( P ‐value = 0.006) and N stage ( P ‐value = 0.043). A nonsignificant decrease in miR‐26b expression level was also observed in OSCC tissues. Additionally, in patients with more aggressive tumoral behavior, including vascular invasion ( P ‐value = 0.012) and positive N stage ( P ‐value = 0.02), significant decreases were found. Conclusions These findings suggest that inactivation of PTEN may have an impact on initiation and progression of OSCC . Additionally, miR‐26b might have a tumor suppressive role in OSCC .