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Meta‐analysis of the prognostic value of the neutrophil‐to‐lymphocyte ratio in oral squamous cell carcinoma
Author(s) -
Wang Yue,
Wang Pengfei,
Andrukhov Oleh,
Wang Tingjian,
Song Siying,
Yan Changxiang,
Zhang Fengqiu
Publication year - 2018
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12688
Subject(s) - neutrophil to lymphocyte ratio , medicine , hazard ratio , oncology , basal cell , predictive value , meta analysis , lymphocyte , carcinoma , survival analysis , gastroenterology , confidence interval
Background A number of studies have assessed the prognostic value of the neutrophil‐to‐lymphocyte ratio ( NLR ) in oral squamous cell carcinoma ( OSCC ), but their results regarding the predictive value of NLR in OSCC are inconsistent. We therefore performed a meta‐analysis to clarify the association between NLR and clinical outcome in OSCC . Methods We searched the MEDLINE and Web of Science to identify potential studies investigating the association between NLR and survival in OSCC . Results A total of 10 studies, enrolling 2135 patients with OSCC , were included. A higher NLR was a negative predictor for both disease‐specific survival (hazard ratio [ HR ] = 1.93, 95% CI : 1.47‐2.54) and overall survival ( HR = 1.56, 95% CI : 1.28‐1.90). Conclusion This suggests a higher NLR is predictive of a poorer prognosis in OSCC . Because determination of NLR is non‐invasive and cost‐effective, it could be widely used for predicting prognosis in OSCC .