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Circulating high mobility group AT‐hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma
Author(s) -
Ren Wenhao,
Gao Ling,
Li Fan,
Qiang Cui,
Li Shaoming,
Zheng Jingjing,
Kong Xinjuan,
Deng Jing,
Cai Guangfeng,
Zhang Hao,
Zhou Minzhan,
Zhi Keqian
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12609
Subject(s) - hmga2 , medicine , biomarker , gastroenterology , receiver operating characteristic , pleomorphic adenoma , basal cell , adenoma , confidence interval , cancer , carcinoma , oncology , pathology , biology , gene , salivary gland , microrna , biochemistry
Background High mobility group AT ‐hook 2 ( HMGA 2) and pleomorphic adenoma gene 1( PLAG 1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA 2 and PLAG 1 levels in blood as a non‐invasive biomarker for oral squamous cell carcinoma ( OSCC ) diagnosis. Methods qRT ‐ PCR was performed to measure circulating HMGA 2 and PLAG 1 levels in OSCC patients (n=43) and matched cancer‐free blood control group (n=21). Clinical data of all patients were recorded. Results Circulating HMGA 2 and PLAG 1 in the 43 OSCC patients was significantly higher than in control group ( P <.001, P =.038, respectively). Furthermore, HMGA 2 expression in OSCC patients with poor‐moderate differentiation was increased compared with well‐differentiated group. However, no significant differences in PLAG 1 expression were detected when differentiation was considered. In addition, the receiver operating characteristic ( ROC ) curve analysis for circulating HMGA 2 revealed an area under the ROC curve of 0.876 (95% confidence interval, 0.793‐0.959; P <.001) with 65.1% sensitivity and 100% specificity in discriminating OSCC from controls at a cutoff value of 14.380, demonstrating significant diagnostic value for OSCC . Conclusion Circulating HMGA 2 levels are increased in OSCC patients and may potentially serve as a significant index to evaluate OSCC diagnosis.