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Immunosurveillance profile of oral squamous cell carcinoma and oral epithelial dysplasia through dendritic and T‐cell analysis
Author(s) -
Pellicioli Ana Carolina Amorim,
Bingle Lynne,
Farthing Paula,
Lopes Márcio Ajudarte,
Martins Manoela Domingues,
Vargas Pablo Agustin
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12597
Subject(s) - immunosurveillance , epithelial dysplasia , dendritic cell , immune system , oral lichen planus , medicine , pathology , dysplasia , cancer , cd8 , antigen , plasmacytoid dendritic cell , cancer research , immunology
Oral squamous cell carcinomas ( OSCC s) can arise from potentially malignant disorders, such as leukoplakia. The immune system plays an important role recognizing tumour precursor cells. However, due to immuno‐editing mechanisms cancer cells are able to escape immune system surveillance. Objective To evaluate the profile of dendritic (Langerhans and plasmacytoid) and T cells in OSCC and oral epithelial dysplasia ( OED ) and correlate these findings with clinical data. Materials and Methods Fifty cases of OSCC and 48 of OED were immunostained for CD 1a and CD 83 dendritic Langerhans cells ( DLC ), CD303 plasmacytoid dendritic cells (pDC) and CD 8 followed by quantitative analysis. Results Analysis revealed a significant decrease in the number of mature CD 83 DLC in OSCC compared with OED . CD 303 positivity was significantly increased in the OSCC group when compared to OED . CD 8‐positive lymphocytes were significantly decreased in OSCC compared with OED lesions. No statistical correlation was found with clinical data. Conclusion The number of mature dendritic cells ( DC ) was decreased in OSCC compared with OED lesions suggesting that either these cells might have migrated to lymph nodes to present the tumour antigens and activate the immune system or cytokines secreted by the tumour microenvironment are inhibiting the adequate maturation of DLC . The numbers of pDC were significantly increased in the OSCC group compared with the OED group. This suggests they may play an important role in the defence against tumours although it is not clear whether this is promoting or inhibiting malignant progression.