Premium
The prognostic value of B7‐H6 protein expression in human oral squamous cell carcinoma
Author(s) -
Wang Jiongke,
Jin Xin,
Liu Jiajia,
Zhao Kui,
Xu Hao,
Wen Jing,
Jiang Lu,
Zeng Xin,
Li Jing,
Chen Qianming
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12586
Subject(s) - immunohistochemistry , medicine , basal cell , proportional hazards model , stage (stratigraphy) , oncology , carcinoma , survival analysis , cell , pathology , t stage , cancer , biology , paleontology , genetics
Objectives To investigate the expression and prognostic value of B7‐H6 protein in oral squamous cell carcinoma tissues. Materials and Methods A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia (OLK) samples, and 17 normal controls were included in the analysis. The expression of B7‐H6 in oral squamous cell carcinoma, OLK, and normal controls was evaluated by immunohistochemical assay. Results The B7‐H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa. Furthermore, a significant relationship was found between the expression of B7‐H6 and differentiation, but not with age, sex, tumor size, lymph metastasis, clinical stage, or recurrence. Further, the survival curves showed that B7‐H6 was an independent prognostic factor of overall survival and disease‐free survival in oral squamous cell carcinoma. Moreover, multivariate survival analysis by COX proportional hazard regression model revealed that the recurrence, differentiation, and expression of B7‐H6 were related to the prognosis. Lastly, we verified the prognostic value of B7‐H6 in oral squamous cell carcinoma. Conclusions B7‐H6 may represent a new prognostic marker for oral squamous cell carcinoma.