Premium
Phenotypic characterization of oral mucosa: what is normal?
Author(s) -
Valach Jaroslav,
Foltán René,
Vlk Marek,
Szabo Pavol,
Smetana Karel
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12556
Subject(s) - oral mucosa , filaggrin , epithelium , leukoplakia , keratin , phenotype , keratin 14 , pathology , fornix , medicine , oral leukoplakia , biology , cancer , dermatology , genetics , gene , genetically modified mouse , transgene , atopic dermatitis , hippocampus
Background Knowledge of the phenotypic pattern of oral squamous epithelium is important in the histopathologic evaluation of lesions including cancer. The literature on normal epithelium is controversial as the phenotype has not been evaluated in samples from completely healthy tissue donors without a history of tobacco and alcohol exposure. Methods In this study, we evaluated normal upper lip fornix and gingival mucosa from carefully selected young healthy donors without a history of smoking and alcohol exposure, and keratin types 8, 10, 14, and 17, filaggrin, and Ki67 were investigated in these donors. The results were compared with profile of epithelium from leukoplakia. Results The results demonstrated that the phenotypic patterns of gingiva and upper lip fornix mucosa were different. Surprisingly, a high proportion of gingival samples exhibited keratin 8 and a suprabasal signal for keratin 14. These patterns were compared with that of human oral leukoplakia, and some phenotypic similarities were noted. Conclusions These results demonstrated oral epithelium phenotypic plasticity based on functional requirements of the microenvironment, which can be used in diagnosis.