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Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia
Author(s) -
Thiem Daniel G. E.,
Schneider Schamiem,
Venkatraman Narayan T.,
Kumar Vinay V.,
Brieger Jürgen,
Frerich Bernhard,
Kämmerer Peer W.
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12544
Subject(s) - hyperkeratosis , medicine , leukoplakia , malignant transformation , dysplasia , angiogenesis , epithelial dysplasia , tongue , pathology , basal cell , microvessel , oral submucous fibrosis , vascular endothelial growth factor , oral and maxillofacial pathology , cancer , vegf receptors , dentistry
Background Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia ( OL ). Materials and methods A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia ( OL ; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia ( OL ‐ SIN 1; n = 33), with moderate dysplasia ( OL ‐ SIN 2; n = 13) and leukoplakia‐derived oral squamous cell carcinoma ( OL ‐ OSCC ; n = 36)] were evaluated for microvessel density ( MVD ), vessel diameter as well as for vascular endothelial growth factor ( VEGF ‐A) expression. Data were compared within the groups. Results For MVD , there were significant differences between OL and OL ‐ SIN 2/ OL ‐ OSCC ( P < 0.05) and between OL ‐ SIN 1 and OL ‐ OSCC ( P < 0.05). For OL ‐ OSCC , vessel diameters were significantly increased compared with OL ( P < 0.05). Expression of VEGF ‐A increased significantly gradually from OL ‐ SIN 1 to OSCC (each P < 0.05). This was especially evident for lesions of the tongue when compared to the others. Conclusion Angiogenesis increases during the transition from OL through dysplasia to OL ‐ OSCC . In particular, OL ‐ OSCC s of the tongue, VEGF ‐A expression may be used for estimation of malignant progression of OL .