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Evaluation of salivary oxidate stress biomarkers, nitric oxide and C‐reactive protein in patients with oral lichen planus and burning mouth syndrome
Author(s) -
Tvarijonaviciute Asta,
AznarCayuela Cristina,
Rubio Camila P.,
Ceron José J.,
LópezJornet Pia
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12522
Subject(s) - saliva , nitric oxide , burning mouth syndrome , oral lichen planus , reactive oxygen species , oxidative stress , nitrite , antioxidant , c reactive protein , trolox , ferric reducing ability of plasma , medicine , gastroenterology , antioxidant capacity , chemistry , nitrate , immunology , biochemistry , inflammation , organic chemistry
Objectives The aim of this study was to evaluate oxidative stress factors and C‐reactive protein in the saliva of patients with oral lichen planus ( OLP ) and burning mouth syndrome ( BMS ). Methods This consecutive, cross‐sectional study included 20 patients with OLP , 19 with burning mouth syndrome ( BMS ), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire ( OHIP ‐14) and the xerostomia inventory. The following parameters were measured in whole non‐stimulated saliva: trolox equivalent antioxidant capacity ( TEAC ); total antioxidant capacity ( TAC ); cupric reducing antioxidant capacity ( CUPRAC ); ferric reducing ability of plasma ( FRAP ); C‐reactive protein ( CRP ); nitric oxide; nitrates; and nitrites. Results The OLP group presented statistically significant differences in reactive oxygen species ( ROS ) (29 600 cps) in comparison with the control group (39 679 cps) ( P < 0.05). In the BMS group, ROS was 29 707 cps with significant difference in comparison with the control group ( P < 0.05). Significantly higher salivary nitric oxide (145.7 μmol) and nitrite (141.0 μmol) levels were found in OLP patients in comparison with control group ( P < 0.05). Conclusion Increases in nitric oxide and C‐reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings.