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Glypican‐3 distinguishes aggressive from non‐aggressive odontogenic tumors: a preliminary study
Author(s) -
Mendes Ramon Barreto,
Dias Rosane Borges,
Figueiredo Andreia Leal,
Gurgel Clarissa Araújo,
Santana Filho Manoel,
Melo Leonardo Araújo,
Trierveiler Marília,
Cury Patrícia Ramos,
Leonardi Rosalia,
Dos Santos Jean Nunes
Publication year - 2017
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12501
Subject(s) - adenomatoid odontogenic tumor , ameloblastoma , odontogenic tumor , pathology , glypican 3 , odontogenic , medicine , keratocystic odontogenic tumor , immunohistochemistry , anatomy , maxilla
Background Glypican‐3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican‐3 in a series of aggressive and non‐aggressive odontogenic tumors. Methods Fifty‐nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOT s including five associated with Gorlin–Goltz syndrome) and non‐aggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican‐3 using immunohistochemistry. Results Glypican‐3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumors including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases ( P > 0.05; Fisher's exact Test). All cases of unicystic ameloblastoma ( n = 4), adenomatoid odontogenic tumor ( n = 5), and calcifying cystic odontogenic tumor ( n = 2) were negative. Conclusions This provided insights into the presence of glypican‐3 in odontogenic tumors. This protein distinguished aggressive from non‐aggressive odontogenic tumors.