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Correlation of serum ANA and direct immunofluorescence studies in elderly Thai patients with red and white oral lesions
Author(s) -
Thongprasom Kobkan,
Prapinjumrune Chanwit,
Kanjanabuch Patnarin,
YoungnakPiboonratanakit Pornpan,
Preuksrisakul Titipong
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12444
Subject(s) - medicine , anti nuclear antibody , gastroenterology , lesion , indirect immunofluorescence , immunofluorescence , antibody , pathology , immunology , autoantibody
Objectives This study investigated the presence of serum antinuclear antibodies ( ANA ) profile and direct immunofluorescence ( DIF ) evaluation in elderly Thai patients with red and white oral lesions. Materials and Methods Thirty‐two patients with red and white oral lesions were divided into two groups: group I consisted of 10 cases not taking medications, while group II consisted of 12 cases taking medications, and 30 healthy subjects as a control group. Blood samples were used to determine the ANA profile. DIF was investigated in the lesion containing groups. Results Serum ANA was found in six cases (60%) in group I, eight cases (66.7%) in group II , and 19 cases (63.3%) in the control group. There were no significant differences between group I and group II and the control group ( P > 0.05). Serum ANA was most commonly found in patients taking hypolipidemics (80%), followed by antihypertensives (71.4%), NSAID s (50%), hypoglycemics (50%), and others (66.7%). The anticytoplasmic staining frequency in group II was higher compared with group I and the control group. Anti‐ds DNA antibodies were not found in any group. Conclusions Elderly patients with red and white oral lesions who were taking medications had a higher serum ANA frequency than group I and the control group.