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Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?
Author(s) -
Sonis Stephen T.,
Amaral Mendes Rui
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12436
Subject(s) - carcinogenesis , pi3k/akt/mtor pathway , oral lichen planus , medicine , cancer research , carcinogen , immunology , signal transduction , biology , cancer , genetics
The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graft‐versus‐host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.