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NLRP 3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis
Author(s) -
Bidoki Alireza Zare,
Harsini Sara,
Sadr Maryam,
Soltani Samaneh,
Mohammadzadeh Mahsa,
Najafi Shamsolmoulouk,
Rezaei Nima
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12332
Subject(s) - recurrent aphthous stomatitis , genotype , single nucleotide polymorphism , genotyping , allele , immune system , medicine , case control study , polymorphism (computer science) , immunology , allele frequency , inflammasome , genotype frequency , gastroenterology , stomatitis , genetics , gene , biology , inflammation
Background Recurrent aphthous stomatitis ( RAS ) is a common disorder with an unclear etiopathogenesis. Involvement of the immune system in the development of this condition is strongly suggested. As the variations in the inflammasome‐related NLRP 3 gene have been suggested to affect immune system activity, this case–control study was performed to determine whether these genetic variants are associated with RAS . Methods We studied a group of 69 Iranian patients with RAS in comparison with 56 healthy controls. We determined four single nucleotide polymorphisms ( SNP s) of NLRP 3 and performed association analyses of NLRP 3. Genotyping was conducted using the TaqMan method. Results The NLRP 3 rs3806265 T allele was significantly more frequent in the patients with RAS than in the healthy controls ( P = 0.003). While a significant negative association was found between the C allele at the same position with RAS ( P = 0.003), the TT genotype was significantly more frequent at position rs3806265 in NLRP 3 in patient group than in the controls ( P = 0.002). However, the frequency of CT genotype at the same position was significantly higher in healthy controls than in the case category ( P = 0.002). Conclusions Considering the high frequency of the presence of NLRP 3 rs3806265 TT genotype in patients with RAS , it seems that this gene polymorphism could affect individual susceptibility to RAS .