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Oxidative stress factors and C‐reactive protein in patients with oral lichen planus before and 2 weeks after treatment
Author(s) -
Hashemy Seyed Isaac,
Gharaei Shideh,
Vasigh Samaneh,
Kargozar Sanaz,
Alirezaei Banafsheh,
Jahed Keyhani Fereshteh,
Amirchaghmaghi Maryam
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12326
Subject(s) - oral lichen planus , malondialdehyde , oxidative stress , medicine , c reactive protein , gastroenterology , pathogenesis , antioxidant , case control study , immunology , inflammation , biology , biochemistry
Objectives Oral lichen planus ( OLP ) is an inflammatory disease with an unknown origin. Oxidative stress is suspected to play a role in its pathogenesis. The aim of this study was to evaluate serum levels of oxidative stress factors and C‐reactive protein in patients with OLP . Materials & Methods In this case–control study, 25 patients with OLP and 23 control subjects were enrolled. Serum levels of C‐reactive protein ( CRP ), malondialdehyde ( MDA ), and total antioxidant capacity ( TAC ) were investigated in both groups. In case group, all these factors were re‐evaluated after 14 days of treatment. The characteristics of the lesions were also recorded at each visit. Results Serum levels of MDA were significantly higher ( P = 0.009), and TAC was significantly lower ( P < 0.001) in patients with OLP . There were no significant differences between serum levels of TAC , CRP , and MDA in patients with OLP before and after treatment ( P = 0.174, P = 0.556, P = 0.194, respectively). However, the difference in serum levels of TAC between erosive and atrophic patients with keratotic OLP was significant ( P = 0.024). Conclusion We concluded patients with OLP have increased of serum MDA and the decrease of serum TAC compared with the healthy subjects, and 14‐day treatment of OLP did not have any effect on serum levels of oxidative stress factors.