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The positive correlation of the CCL 2‐ CCR 2 axis with the disease activity may indicate the fundamental role in the pathogenesis of oral lichen planus
Author(s) -
Yin Jingfang,
Yang Xi,
Zeng Qi,
Yang Linglan,
Cheng Bin,
Tao Xiaoan
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12325
Subject(s) - pathogenesis , oral lichen planus , immunohistochemistry , reticular connective tissue , triamcinolone acetonide , pathology , medicine , chemistry , gastroenterology , endocrinology , immunology
Background The important roles of CCL 2 and its receptor CCR 2 had been reported in a series of inflammatory disorders. However, few studies investigated the potential role of CCL 2/ CCR 2 axis in oral lichen planus ( OLP ). Therefore, this study aimed to detect the expression of CCL 2 and CCR 2 in OLP lesions and compare their changes before and after treatment. Methods CCL 2 and CCR 2 expression was investigated using immunohistochemical staining and real‐time RT ‐ PCR in 32 patients with OLP and eight controls. Moreover, changes in their expression after treatment with triamcinolone acetonide were assessed in lesions from three patients. Results CCL 2+ and CCR 2+ cells were few in the controls and remarkably increased in the epithelial and subepithelial layers of lesions ( n = 32, all P < 0.001). However, the densities of CCL 2+ and CCR 2+ cells were not significantly different between reticular ( n = 12) and erythematous⁄erosive lesions ( n = 20), although they significantly decreased after treatment (627.7 ± 108.2 vs. 258.3 ± 148.3, P = 0.017; 1034.7 ± 74.6 vs. 648 ± 77.6, P = 0.003, respectively). CCL 2+/ CCR 2+ cell numbers were positively correlated with disease activity (correlation coefficient, 0.588; P < 0.001; correlation coefficient, 0.409; P = 0.02, respectively). Conclusions The results of this study indicated that the CCL 2‐ CCR 2 axis was involved in the pathogenesis of OLP and was positively correlated with disease activity.