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Prognostic implication of CD 57, CD 16, and TGF ‐β expression in oral squamous cell carcinoma
Author(s) -
Taghavi Nasim,
Bagheri Sara,
Akbarzadeh Alireza
Publication year - 2016
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12320
Subject(s) - basal cell , transforming growth factor , cancer research , carcinoma , cell , chemistry , microbiology and biotechnology , biology , medicine , pathology , biochemistry
Background Natural killer ( NK ) cells are important immune effector cells against tumors especially in the absence or reducing MHC class I antigen. Downregulation of CD 16 receptor is accompanied by decreasing NK cell‐killing activity. It has also been shown that some of tumor cells can evade from immune system through producing transforming growth factor beta ( TGF ‐β) and affect prognosis. The objective of this study was to evaluate the prognostic significance of CD 57 + and CD 16 + cells and TGF ‐β expression in samples of oral squamous cell carcinoma ( OSCC ). Methods CD 57, CD 16, and TGF ‐β expressions were examined immunohistochemically in 57 cases of OSCC . The relationship between markers’ expression and clinicopathologic data using bivariate and multivariate analysis was assessed. Results Multivariate analysis revealed that CD 57 expression [ HR 17.34 (95% CI 3.815–78.830); P < 0.001] and mode of invasion [ HR 0.362 (95% CI 0.138–0.947); P = 0.038] correlated with survival rate, but no relation between CD 57 expression and mode of invasion was seen ( P = 0.96). Furthermore, no correlation between CD 57, CD 16, and TGF ‐β expression was found. Conclusion These findings suggest that CD 57 expression and mode of invasion are independent prognostic factors of survival in OSCC patients.