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Phenotypic plasticity and epithelial‐to‐mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma
Author(s) -
Vig Navin,
Mackenzie Ian C.,
Biddle Adrian
Publication year - 2015
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12306
Subject(s) - phenotypic plasticity , epithelial–mesenchymal transition , epigenetics , phenotype , biology , malignancy , metastasis , cancer research , motility , phenotypic switching , mesenchymal stem cell , cell , basal cell , pathology , cancer , medicine , microbiology and biotechnology , genetics , gene
It is increasingly recognised that phenotypic plasticity, apparently driven by epigenetic mechanisms, plays a key role in tumour behaviour and markedly influences the important processes of therapeutic survival and metastasis. An important source of plasticity in malignancy is epithelial‐to‐mesenchymal transition ( EMT ), a common epigenetically controlled event that results in transition of malignant cells between different phenotypic states that confer motility and enhance survival. In this review, we discuss the importance of phenotypic plasticity and its contribution to cellular heterogeneity in oral squamous cell carcinoma with emphasis on aspects of drug resistance and EMT .