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Association of interleukin 12A gene polymorphisms with oral lichen planus in Chinese population
Author(s) -
Jiang Chenyan,
Yao Hui,
Cui Bin,
Zhou Yongmei,
Wang Yufeng,
Tang Guoyao
Publication year - 2015
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12271
Subject(s) - oral lichen planus , genotype , single nucleotide polymorphism , snp , allele , immunology , biology , allele frequency , genetic predisposition , genetics , gene
Background Oral lichen planus ( OLP ) is a common autoimmune disorder with genetic and environmental factors contributing to its etiology. Interleukin ( IL ) 12 is a pro‐inflammatory cytokine, which favors the differentiation of T helper 1 (Th1) cells, and forms a link between innate resistance and adaptive immunity. This study aimed to investigate the association between OLP susceptibility and clinical type in Chinese Han population with single‐nucleotide polymorphisms ( SNP s) of IL ‐12A gene. Methods Five SNP s of the IL ‐12A gene at positions rs2243115, rs2243123, rs583911, rs568408, and rs2243143 were performed in 292 patients with OLP and 686 healthy controls from East China. The five SNP s were genotyped by TaqMan PCR method. The genotype and allelic frequencies were calculated and analyzed. Results There was a significant difference in rs568408 genotype distributions between patients and controls ( P = 0.043). Additionally, there were highly significant increases in rs568408 genotype distributions and allele A frequencies in the erosive OLP group as compared to the control group ( P = 0.011, OR = 1.76, 95% CI : 1.133 –2.732). Conclusions Our study indicated that the rs568408 variation in IL ‐12A gene could influence disease susceptibility, and was associated with the severity of OLP in our East Chinese cohort.