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p‐ A kt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study
Author(s) -
Pontes Hélder Antônio Rebelo,
Pontes Flávia Sirotheau Corrêa,
Jesus Adriana Souza,
Soares Maiza Cristina Pereira,
Gonçalves Fábio Luiz Neves,
Lucena Botelho Tessa,
Carmo Ribeiro Jaciane,
Santos Pinto Décio
Publication year - 2015
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12268
Subject(s) - immunohistochemistry , immunostaining , medicine , pathology , basal cell , carcinoma , metastasis , stage (stratigraphy) , oncology , cancer , biology , paleontology
Background The aim of this study was to evaluate, through immunohistochemical reaction in samples of oral squamous cell carcinoma, the correlation between the expression status of protein kinase B (p‐ A kt) and patient survival as well as histological grade and some clinicopathological features. Methods Samples were collected from 46 patients with oral squamous cell carcinoma. The immunohistochemical expression of p‐ A kt was analysed, as were clinicopathological features including the use of tobacco, tumour stage, size and infiltration of metastatic lymph nodes. The association of immunostaining with histological grade was analysed in 40 patients. The associations were examined for statistical significance using a chi‐square test. Overall survival rates were estimated by the K aplan– M eier method and compared using a log rank test ( P > 0.05). Results The results indicated a statistically significant association with p‐ A kt immunostaining for the variables lymph node metastasis ( P = 0.006), tumour size ( P = 0.044) and survival rate ( P = 0.0298). Conclusion From these results, the present study suggests that high p‐ A kt expression found in oral squamous cell carcinoma patients may contribute to tumour growth, metastasis to regional lymph nodes and shorter survival time.