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Immunohistochemical profile of oral mucosal and head and neck cutaneous melanoma
Author(s) -
Alaeddini Mojgan,
EtemadMoghadam Shahroo
Publication year - 2015
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12235
Subject(s) - mucosal melanoma , microphthalmia associated transcription factor , medicine , immunohistochemistry , ki 67 , head and neck , melanoma , oral mucosa , pathology , dermatology , biology , cancer research , transcription factor , surgery , biochemistry , gene
Background In addition to ultraviolet radiation exposure, various molecular markers may differ between oral mucosal and cutaneous head and neck melanomas and lead to variations in their biologic behavior and prognosis. The aim of this study was to compare four such markers, namely microphthalmia transcription factor ( MITF ), P75, P53, and Ki‐67 in malignant melanomas originating from the oral cavity and head and neck skin. Methods A total of 19 oral mucosal and 23 head and neck cutaneous melanomas were subjected to immunohistochemical analysis using antibodies against MITF , P75, P53, and Ki‐67. Statistical comparison of data was performed by t ‐test and chi‐square analysis ( P < 0.05). Results Significant differences in MITF ( P = 0.016) and Ki‐67 ( P = 0.002) were observed between oral mucosal and cutaneous melanomas. P75 ( P = 0.80) and P53 ( P = 0.76) did not differ significantly, between these locations. Conclusions According to the results obtained in this study, the biological properties of cutaneous and mucosal melanoma differ, especially regarding MITF and Ki‐67.