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IL ‐18 gene polymorphisms in aphthous stomatitis vs. Behçet's disease in a cohort of Egyptian patients
Author(s) -
Hazzaa Hala H. A.,
Rashwan Weam A. M.,
Attia Enas A. S.
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12200
Subject(s) - recurrent aphthous stomatitis , behcet's disease , genotype , allele , medicine , stomatitis , gastroenterology , single nucleotide polymorphism , polymorphism (computer science) , disease , immunology , gene , genetics , biology
Objective A clinical investigation of the potential correlation of two single‐nucleotide polymorphisms at −137 (G/C) and −607 (C/A) in the promoter region of the IL ‐18 gene, with the susceptibility to aphthous stomatitis and Behçet's disease. Patient and Methods This study included 80 aphthous stomatitis patients and 80 patients with Behçet's disease. Eighty healthy subjects were enrolled as a control group. IL ‐18 single‐nucleotide polymorphisms at −607 and −137 regions were analyzed using polymerase chain reaction–restriction fragment length polymorphism analysis. Results The genotype and allele distributions of the two regions did not differ significantly between patients with aphthous stomatitis and controls. The genotype and allele distributions at −607 were significantly different between patients with Behçet's disease [ CC ( P = 0.044), C allele ( P = 0.043), A allele ( P = 0.043)], and controls. The frequency of the GG genotype at position −137 in patients with Behçet's disease was associated only with a higher rate of ocular manifestations ( OR = 1.4, CI = 0.76–2.7, P = 0.031). Conclusion IL ‐18 gene polymorphisms were not associated with any susceptibility to aphthous stomatitis, while a positive association was found with patients with Behçet's disease regarding −607 promoter site. Moreover, patients with Behçet's disease carrying the GG genotype at position −137 had a higher risk of developing ocular manifestations.