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Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis
Author(s) -
Knaś Małgorzata,
Zalewska Anna,
Waszkiewicz Napoleon,
Szulimowska Julita,
Dzięcioł Janusz,
Sierakowski Stanisław,
Waszkiel Danuta
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12166
Subject(s) - lactoferrin , saliva , lysozyme , peroxidase , multiple sclerosis , medicine , salivary gland , endocrinology , immunology , biology , enzyme , biochemistry
Background However, there are some informations on the salivary glands involvement in systemic sclerosis, and there is a lack of any data about salivary glands function depending on systemic sclerosis subsets. Methods The unstimulated and stimulated salivary flow, the activity of peroxidase, the total amount of lactoferrin, lysozyme and s I g A were determined in two subgroups of systemic sclerosis and healthy controls. Results In the unstimulated saliva of both patients groups, the salivary flow, the output of total protein and peroxidase activity were significantly lower; the total: s I g A and lactoferrin were significantly higher as compared with the control. In the stimulated saliva of the patients with limited form, the total lysozyme and peroxidase activity were significantly higher than in the control. In the stimulated saliva of the patients with diffused form, the salivary flow was significantly lower and the total s I g A and peroxidase activity were significantly higher than in the control. Conclusion Systemic sclerosis regardless of its subset affects salivary defense system of human unstimulated and stimulated saliva. Patients with the limited form experience the same impairment of the submandibular glands function as compared with patients with the diffused form. Only patients with the diffused form are deficient in respect of stimulated saliva secretion; the parotid glands of the patients with the limited form have a good secretory capacity in comparison with the healthy control.